Ketamine. For some people with treatment-resistant depression, this experimental therapy proved to be more than just life-changing—it was lifesaving. But how did a drug once used as a battlefield anesthetic evolve into esketamine, a treatment for major depressive illnesses? In this episode, we’ll talk with Dr. Carlos Zarate Jr., who helped lay the groundwork for esketamine for treatment-resistant depression. We’ll learn the history behind the development of esketamine, how it can help with depression, and what the future holds for this innovative line of clinical research.

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Author: National Institute of Mental Health